Commentary on effect of radiosurgery alone vs radiosurgery with whole brain radiation therapy on cognitive function in patients with 1-3 brain metastases by Brown et al. JAMA 2016;316:401-9
نویسنده
چکیده
The team of Brown et al. are to be congratulated for the recent publication of a prospective randomized trial that evaluated cognitive function and tumor control in patients with 1–3 brain metastases (primarily lung).[1] This level 1 evidence provided additional confirmatory support regarding the role of stereotactic radiosurgery (SRS) as a primary management option for patients whose cancer has spread to the brain. The confirmation that SRS reduces the early cognitive function decline in cancer patients compared to the use of whole brain radiation therapy (WBRT) provides additional data that has gradually led to the displacement of reflex WBRT as the usual strategy for brain metastatic disease.
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Whole-brain radiation therapy for brain metastases: detrimental or beneficial?
Stereotactic radiosurgery is frequently used, either alone or together with whole-brain radiation therapy to treat brain metastases from solid tumors. Certain experts and radiation oncology groups have proposed replacing whole-brain radiation therapy with stereotactic radiosurgery alone for the management of brain metastases. Although randomized trials have favored adding whole-brain radiation ...
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